^[1]；当头皮菌群环境失衡，便可能会出现头痒。

 [2-6]；而头皮角质层代谢过快，脱落就形成头屑。

良好的生活习惯是成功的第一步

掌握正确的头皮护理姿势更重要

 [1]。过多刺激会减少头皮皮脂的厚度，通过负反馈机制令皮脂加速分泌，会出现头皮干燥，头皮屑过多的现象；

[7-9]。

[1]. 慕彰磊, 杨勤萍. 头皮屑发病机制研究进展 [J]. 国际皮肤性病学杂志, 2010, 36(1):15-16.

[2]. Bhattacharyya A, Jain N, Prasad S, et al. Evaluation of therapeutic potential of VB-001, a leave-on formulation, for the treatment of moderate adherent dandruff. BMC Dermatology 2017;17(1).

[3]. Szepietowski JC, Kerr K, Schwartz JR, et al. Scalp Stratum Corneum Histamine Levels: Novel Sampling Method Reveals Association with Itch Resolution in Dandruff/Seborrhoeic Dermatitis Treatment. ActaDermatoVenereologica 2011;91(4):404-8.

[4]. Viodé C, Lejeune O, Turlier V, et al. Cathepsin S, a new pruritus biomarker in clinical dandruff/seborrhoeic dermatitis evaluation. EXP DERMATOL 2014;23(4):274-5.

[5]. Erchiga V C , Florencio V D . Malassezia species in skin diseases[J]. Current Opinion in Infectious Diseases, 2002, 15(2):133-142.

[6]. Pierard-Franchimont C, Xhauflaire-Uhoda E, Pierard GE. Revisiting dandruff. Int J CosmetSci 2006 2006-10-01;28(5):311-8.

[7]. Van CutsemJ , Van Gerven F , Fransen J , et al. The in vitro antifungal activity of ketoconazole, zinc pyrithione, and selenium sulfide against Pityrosporum and their efficacy as a shampoo in the treatment of experimental pityrosporosis in guinea pigs[J]. Journal of the American Academy of Dermatology, 1990, 22(6):993-998.

[8]. Angela Sanfilippo, Joseph C. English II. An Overview of Medicated Shampoos Used in Dandruff Treatment. P&T 2006;31(7):396-400.

[9]. 刘斌, 朱里. 硫化硒洗剂治疗马拉色菌毛囊炎 50 例 [J]. 医药导报, 2008(8).

桐乡市皮肤病防治院 皮肤科副主任医师 吴大兴

 T酱/高梦雪

  Iris